INTRAVENOUS ADMINISTRATION OF LARGE DOSAGES OF ADENOSINE OR ADENOSINE-TRIPHOSPHATE WITH MINIMAL BLOOD-PRESSURE FLUCTUATION

Hemodynamic responses, blood gas, and metabolic changes were assessed when large dosages of a pre-mixed solution of adenosine or adenosine t riphosphate (ATP) with catecholamine were intravenously administered i n the conscious, spontaneously breathing rabbit. The present study off ers a simple and effective approach to enabling safe administration of large doses of the potent vasodilators, adenosine or ATP with minimal cardio-respiratory and metabolic changes.