THE THYMOSIN BETA(4) GENE IS STRONGLY ACTIVATED IN NEURAL TISSUES DURING EARLY POSTIMPLANTATION MOUSE DEVELOPMENT

Authors
CARPINTERO P ANADON R DELAMO FF GOMEZMARQUEZ J
Citation
P. Carpintero et al., THE THYMOSIN BETA(4) GENE IS STRONGLY ACTIVATED IN NEURAL TISSUES DURING EARLY POSTIMPLANTATION MOUSE DEVELOPMENT, Neuroscience letters, 184(1), 1995, pp. 63-66
Citations number
17
Categorie Soggetti
Neurosciences
Journal title
Neuroscience letters → ACNP
ISSN journal
03043940
Volume
184
Issue
1
Year of publication
1995
Pages
63 - 66
Database
ISI
SICI code
0304-3940(1995)184:1<63:TTBGIS>2.0.ZU;2-4
Abstract
We studied the temporal and spatial distribution of the mRNA encoding for thymosin beta(4) (T beta(4)), a Small acidic actin-sequestering pe ptide, during the early postimplantation mouse development. Analysis o f total embryo RNA demonstrated a strong activation of T beta(4) gene after gastrulation and coincident with neurulation. In situ hybridizat ion showed that T beta(4) mRNA was strongly expressed in the central n ervous system and peripheral ganglia, paralleling the gradient of neur onal differentiation. An intense signal was also observed in intravent ricular macrophages and blood vessels. The role of T beta(4) in mammal ian neuroembryogenesis is discussed.