THE POLYBACTERIAL LYSATE OLIMUNOSTIM MODULATES LYMPHOCYTE FUNCTION IN-VITRO AND RESTORES DEPRESSED CELLULAR-IMMUNITY IN-VIVO

Immunobiological activity of the polybacterial lysate Olimunostim (P. acnes, K. pneumoniae, S. aureus) was examined by investigating its eff ects on murine lymphocytes. When added to in vitro lymphocyte cultures , Olimunostim induced interleukin-2 (IL-2) biological activity (in a 2 -d culture) and subsequently potentiated lymphocyte proliferation (on day 3); the latter effect was dependent on the presence of adherent ce lls. In vivo, significant enhancement of lymphocyte reactivity to T-mi togens and increase of CD4+ helper-inducer T lymphocytes were observed 3 d after a subcutaneous application of Olimunostim to mire with cell ular immune deficiency. These results confirm the modulatory propertie s of Olimunostim towards lymphocytes both in vitro and in vivo which m ay form a basis for its clinical application.