FOLATE STATUS AND ADENOMATOUS COLONIC POLYPS - A COLONOSCOPICALLY CONTROLLED-STUDY

PURPOSE: The aim of our study was to assess any association of folate with development of colonic adenomas. METHODS: Serum and red blood cel l folate levels were measured in 62 colonoscopically and histologicall y evaluated patients with colon adenomas (Group A) and in 50 selected colonoscopically negative controls (Group B). Patients with colon poly ps underwent colonoscopy for alterations of bowel habits or abdominal pain, and detected polyps were found coincidentally. Controls underwen t colonoscopy for alterations of bowel habits or abdominal pain. There was no difference in hematocrit between the two groups, RESULTS: The mean serum folate level in patients with colonic adenomas was 4.57 ng/ ml +/- 2.8 standard deviations (SD), and the mean red blood cells fola te levels were 536 ng/ml +/- 273.3 (SD). In controls the mean folate l evels in serum and red blood cells were 5.09 ng/ml 2.7 (SD) and 743.8 ng/ml +/- 297.1 (SD), respectively. The red blood cell folate level of colon adenoma patients was statistically lower than the respective le vel of controls at a highly significant level (P < 0.01). CONCLUSIONS: We suggest that depressed red blood cell folate levels are associated with development of colonic adenomas.