COMPARATIVE-STUDY OF LIPIDS, APOPROTEINS AND LIPOPROTEINS IN PATIENTSWITH CORONARY HEART-DISEASE AND IN HEALTHY CONTROLS

We carried out a comparative study of various lipid parameters (apo AI and B, LpAI, Lp(a) and LpBCIII) in coronary heart disease patients (1 9 males and 4 females, mean age 61 +/- 11 years) and in controls (18 m ales and 14 females, mean age 55 +/- 3 years) selected so that cholest erol and triglycerides levels be beneath 6 and 2.3 mmol/l in both popu lations. Apo AI and B were analysed by immunonephelometry and lipopart icles by electroimmunodiffusion Nonparametric statistics tests were pe rformed on account of the small numbers in both groups. Our study conf irms the protective effect of Lp AI but did not show an obvious superi ority of Lp AI quantification compared to apo AI. It highlights the in terest of Lp(a) as an independent and additional risk factor for ather ogenesis: no obvious correlation with any other lipidic parameter was demonstrated. An increase in Lp(a) beyond 0.30 g/l increases atherogen ic risk 2.5 fold. We did not show any benefit of LpBCIII quantificatio n in 'normolipermic' coronary patients. In conclusion, a discriminant analysis including the apo B/apo AI and apo B/LpAI ratios and Lp(a) al lows an accurate classification of 67% of the patients.