OCTREOTIDE (SMS-201-995) AS AN ANTISECRETORY AGENT IN CHOLERA-TOXIN AND BILE-ACID INDUCED INTESTINAL SECRETION IN AN IN-VIVO ANIMAL STUDY

The effect of Octreotide (SMS 201-995), synthetic somatostatin analogu e on small intestinal and colonic fluid secretion induced respectively by cholera toxin (CT) and deoxycholic acid (DCA) was investigated in rabbits using in vivo isolated loops. After exposure to CT and DCA, ma rked fluid accumulation was observed in the small intestinal and colon ic loops, alongwith elevation of jejunal and colonic mucosal cyclic AM P concentrations. Octreotide inhibited CT and DCA induced small intest inal and colonic secretion, dose-dependently. This anti-secretory effe ct was observed after both intramuscular and oral administration of oc treotide. In contrast, octreotide did not affect the elevated mucosal cyclic AMP concentrations. These results suggest that octreotide inhib its CT and DCA induced intestinal secretion, and this anti-secretory e ffect is produced by affecting processes beyond cyclic AMP formation.