K. Ossowska et S. Wolfarth, STIMULATION OF GLUTAMATE RECEPTORS IN THE INTERMEDIATE CAUDAL STRIATUM INDUCES CONTRALATERAL TURNING, European journal of pharmacology, 273(1-2), 1995, pp. 89-97
The aim of the present study was to investigate the role of striatal N
MDA, kainate and AMPA receptors in the turning behaviour of rats. N-me
thyl-D-aspartate (NMDA, 500 ng/0.5 mu l), kainic acid (50 ng/0.5 mu l)
or pha-amino-3-hydroxy-5-methyl-4-isoxasole-propionic acid (AMPA, 100
0 ng/0.5 mu l), injected into the intermediate and caudal parts of the
caudate-putamen, induced contralateral head turns and rotations. This
effect was delayed or was not observed after administration of the co
mpounds into the globus pallidus. The antagonist of non-NMDA receptors
, 6,7-dinitroquinoxaline-2,3-dione (DNQX, 1000 ng/0.5 mu l), antagoniz
ed the contralateral head turns and rotations induced by AMPA (1000 ng
/0.5 mu l) or kainic acid (50 ng/0.5 mu l), and evoked per se (2000 ng
/0.5 mu l) the ipsilateral head turns and rotations. The NMDA receptor
antagonist, (+/-)-2-amino-5-phosphonopentanoic acid (AP5, 1000 ng/0.5
mu l), induced mainly ipsilateral head turns and rotations; when inje
cted in a dose of 500 ng/0.5 mu l, it inhibited the contralateral head
turns and rotations after NMDA. The results seem to suggest that the
contralateral head turns and rotations induced by stimulation of NMDA,
AMPA and kainate receptors in the intermediate and caudal parts of th
e caudate-putamen may result from activation of the gamma-aminobutyrat
e (GABA)-ergic strionigral pathway.