We examined the effects of physical exercise on smoking relapse. Twent
y previously sedentary female smokers were randomly assigned to smokin
g cessation plus exercise or smoking cessation with frequency contact
control. The smoking cessation program included 12 professionally led
sessions over 12 weeks. Exercise treatment included three supervised e
xercise sessions per week for 15 weeks. Contact control included three
women's health/wellness lectures per week for 15 weeks. Smoking absti
nence was validated by carbon monoxide and saliva cotinine. Mean exerc
ise attendance for exercise subjects was 88% with an increase in estim
ated VO2 of 25%. The percentage of subjects who quit for 24 hours was
80% for the exercise and 90% for the contact group. One subject in the
contact group remained abstinent at the end of the 12-week treatment
and at 1-, 3-, and 12-month follow-ups, whereas three subjects in the
exercise group were abstinent at these time points. These results sugg
est that exercise training improves short-term quit rates and may prov
e a useful strategy for long-term maintenance of smoking cessation.