MAPPING OF THE NEP RECEPTOR TYROSINE KINASE GENE TO HUMAN-CHROMOSOME 6P21.3 AND MOUSE CHROMOSOME 17C

The mouse receptor tyrosine kinase (RTK) NEP, also called Ptk-3, is wi dely expressed, with high levels in proliferating neuroepithelia of mo use embryos. The recently described human discoidin domain receptor (D DR) has a predicted amino acid sequence 93% identical to that of murin e NEP and may be its human homologue. We have mapped the gene encoding NEP in human and mouse by fluorescence in situ hybridization using a mouse cDNA probe. The NEP/Nep gene maps to human chromosome 6p21.3 and mouse chromosome 17C, respectively. This places the NEP/Nep gene at, or near, the major histocompatibility (MHC) locus-HLA in human and H2 in mouse, respectively. Based on its pattern of expression during deve lopment, NEP and Nep represent candidate genes for several MHC-linked developmental abnormalities in human and mouse. (C) 1995 Academic Pres s, Inc.