ON THE ROLE OF THE NITROGEN ATOM IN DYNEMICIN-A

Authors
MAIER ME ABEL U
Citation
Me. Maier et U. Abel, ON THE ROLE OF THE NITROGEN ATOM IN DYNEMICIN-A, Synlett, (1), 1995, pp. 38-40
Citations number
33
Categorie Soggetti
Chemistry Inorganic & Nuclear
Journal title
Synlett → ACNP
ISSN journal
09365214
Issue
1
Year of publication
1995
Pages
38 - 40
Database
ISI
SICI code
0936-5214(1995):1<38:OTROTN>2.0.ZU;2-D
Abstract
The dynemicin analogs 13a,b have been synthesized from the cyclohexeno ne derivative 8b via the enediyne aldehyde 12. NMR analysis indicates that 13a,b exist as rotamers around the C-aryl bond. This points to th e role of the nitrogen atom in dynemicin A for fixation of the conform ation of the aryl ring.