SYNTHESIS OF SIALIC-ACID LIPID CONJUGATES AND THEIR NEURITOGENIC EFFECTS ON N1E.115 NEUROBLASTOMA-CELLS

Authors
VEENEMAN GH VANDERHULST RGA VANBOECKEL CAA PHILIPSEN RLA RUIGT GSF TONNAER JADM VANDELFT TML KONINGS PNM
Citation
Gh. Veeneman et al., SYNTHESIS OF SIALIC-ACID LIPID CONJUGATES AND THEIR NEURITOGENIC EFFECTS ON N1E.115 NEUROBLASTOMA-CELLS, Bioorganic & medicinal chemistry letters, 5(1), 1995, pp. 9-14
Citations number
15
Categorie Soggetti
Chemistry Inorganic & Nuclear","Chemistry Medicinal
Journal title
Bioorganic & medicinal chemistry letters → ACNP
ISSN journal
0960894X
Volume
5
Issue
1
Year of publication
1995
Pages
9 - 14
Database
ISI
SICI code
0960-894X(1995)5:1<9:SOSLCA>2.0.ZU;2-H
Abstract
Several sialic acid-lipid conjugates having one or more sialic acid re sidues were prepared via phosphite and methylthiomethyl intermediates. The synthetic compounds were found to promote neurite outgrowth on N1 E.115 neuroblastoma cells. In particular, the trisialocholesterol deri vative 19 exhibited potent neuritogenic activity.