INHIBITORS OF THE ADENOVIRUS TYPE-2 PROTEINASE BASED ON SUBSTRATE-LIKE TETRAPEPTIDE NITRILES

Authors
CORNISH JA MURRAY H KEMP GD GANI D
Citation
Ja. Cornish et al., INHIBITORS OF THE ADENOVIRUS TYPE-2 PROTEINASE BASED ON SUBSTRATE-LIKE TETRAPEPTIDE NITRILES, Bioorganic & medicinal chemistry letters, 5(1), 1995, pp. 25-30
Citations number
22
Categorie Soggetti
Chemistry Inorganic & Nuclear","Chemistry Medicinal
Journal title
Bioorganic & medicinal chemistry letters → ACNP
ISSN journal
0960894X
Volume
5
Issue
1
Year of publication
1995
Pages
25 - 30
Database
ISI
SICI code
0960-894X(1995)5:1<25:IOTATP>2.0.ZU;2-N
Abstract
Tetrapeptides containing the substrate derived P-4-P-1 residues Leu-Al a-Gly-Gly and C-terminal ester, acid, amide, nitrile and dimethylaceta l functionalities were synthesised and tested as inhibitors of the ade novirus type 2 proteinase. The acids and amides did not act as inhibit ors and the dimethyl acetals and the nitriles served as moderate and g ood reversible inhibitors respectively.