KINAMYCIN BIOSYNTHESIS - SYNTHESIS, DETECTION, AND INCORPORATION OF KINOBSCURINONE, A BENZOL[B]FLUORENONE

Authors
GOULD SJ MELVILLE CR
Citation
Sj. Gould et Cr. Melville, KINAMYCIN BIOSYNTHESIS - SYNTHESIS, DETECTION, AND INCORPORATION OF KINOBSCURINONE, A BENZOL[B]FLUORENONE, Bioorganic & medicinal chemistry letters, 5(1), 1995, pp. 51-54
Citations number
19
Categorie Soggetti
Chemistry Inorganic & Nuclear","Chemistry Medicinal
Journal title
Bioorganic & medicinal chemistry letters → ACNP
ISSN journal
0960894X
Volume
5
Issue
1
Year of publication
1995
Pages
51 - 54
Database
ISI
SICI code
0960-894X(1995)5:1<51:KB-SDA>2.0.ZU;2-I
Abstract
The kinamycin antibiotics, derived from a benz[a]anthraquinone precurs or, were recently shown to be 5-diazobenzo[b]fluorene quinones. A 5-ke tobenzo[b]fluorene quinone has been synthesized and shown to be presen t in Streptomyces murayamaensis fermentations, and a deuterium-labeled sample of this metabolite, kinobscurinone, has been incorporated bios ynthetically into kinamycins C and D.