TRICARBONYL ETA-16 ARENE CHROMIUM(0) BASED ANTITUMOR AGENTS

Authors
JONES GB MATHEWS JE
Citation
Gb. Jones et Je. Mathews, TRICARBONYL ETA-16 ARENE CHROMIUM(0) BASED ANTITUMOR AGENTS, Bioorganic & medicinal chemistry letters, 5(1), 1995, pp. 93-96
Citations number
13
Categorie Soggetti
Chemistry Inorganic & Nuclear","Chemistry Medicinal
Journal title
Bioorganic & medicinal chemistry letters → ACNP
ISSN journal
0960894X
Volume
5
Issue
1
Year of publication
1995
Pages
93 - 96
Database
ISI
SICI code
0960-894X(1995)5:1<93:TEACBA>2.0.ZU;2-P
Abstract
Novel arene chromium carbonyl complexed mustard agents have been prepa red. The metal carbonyl group modulates mustard alkylative ability as evidenced by 4-NBP assay. Antitumor evaluation against the human colon tumor line HCT-116 however showed no clear correlation between alkyla tive ability and antitumor activity of the mustard agents, in part a c onsequence of the inherent cytotoxicity of the metal carbonyl group in this screen.