SERUM INTACT PARATHYROID-HORMONE IN A RANDOM-POPULATION SAMPLE OF MENAND WOMEN - RELATIONSHIP TO ANTHROPOMETRY, LIFE-STYLE FACTORS, BLOOD-PRESSURE, AND VITAMIN-D

Intact parathyroid hormone (PTH) in serum was determined in a random p opulation sample and was related to age, sex, body composition, life-s tyle factors, blood pressure, blood lipids, plasma fibrinogen, and ser um IGF-1, osteocalcin, and vitamin D. Within the framework of the WHO MONICA Project in the city of Goteborg, Sweden, 181 men and 166 women aged 25-64 years were studied. Intact PTH concentrations varied with a ge but were similar in both sexes (range 4-82 ng/liter) [mean (+/- SD) 23.8 +/- 10.4 ng/liter in men and 25.1 +/- 10.6 ng/liter in women]. I ntact PTH concentrations increased with increasing age, body mass inde x, systolic blood pressure, and 1,25(OH)(2)D-3 and decreased with incr easing 25(OH)D-3 in all subjects. Additionally, in men, intact PTH cor related positively to diastolic blood pressure and negatively to coffe e consumption. In women, PTH also correlated negatively to smoking and IGF-1. In a multivariate analysis including all variables, age lost i ts significance. In both sexes there were independent positive relatio ns between intact PTH and body mass index and 1,25(OH)(2)D-3, and nega tive relations between PTH and smoking habits as well as 25(OH)D-3; am ong men there was also negative relations between PTH and coffee consu mption. The results indicate that life-style factors such as smoking a nd coffee consumption decrease the serum concentration of intact PTH, and the same effect is seen in individuals with low body mass index. C offee intake, smoking, and low body mass index are also known to adver sely affect bone mineral content, highlighting the relationship betwee n PTH and bone metabolism.