',4'-DIFLUOROBIPHENYL-4-YL)-2-METHYL-4-OXOBUTANOIC ACID AND ITS DERIVATIVES

Friedel-Crafts reaction of itaconic anhydride (III) with 2,4-difluorob iphenyl (II) afforded unsaturated acid IV which was hydrogenated to gi ve ',4'-difluorobiphenyl-4-yl)-2-methyl-4-oxobutanoic acid (I). A seri es of functional derivatives and salts of the acid I has been prepared . The antiinflammatory effect of these compounds was compared with tha t of acid I using selected experimental inflammation models. The analg esic activity in the intraperitoneal irritation test was also evaluate d. In the case of (R)-(+)-1-phenylethylamide Vf the ratio of the diast ereoisomers was determined by HPLC.