UNUSUAL SECONDARY TUMORS AFTER CHILDHOOD LYMPHOID MALIGNANCY

Second malignant neoplasms (SMN) in individuals who survived childhood cancer have been reported with increasing frequency during the last d ecades. The overall probability of developing second malignancy for ch ildren treated for cancer was estimated at about 2-5% at 25 years. In children, the tumors most often associated with the development of SMN are retinoblastoma and Hodgkin's disease. We report two cases of unus ual second tumors in two patients cured of lymphoid malignancy: one bo y cured of acute lymphoblastic leukemia developed mediastinal; ganglio neuroma nine years later and one girl had gastric carcinoma seven year s after Hodgkin's disease. Both developed a tumor in nonirradiated are as.Gastric carcinoma and ganglioneuroma are not reported as recurrent SMN in survivors after childhood cancer, with one single case of gastr ic carcinoma and one of ganglioneuroblastoma having been reported as s econd tumor in survivors after childhood cancer. (C) 1995 Wiley-Liss, Inc.