LARGE AMOUNTS OF POLYLACTIC ACID IN CONTACT WITH DIVIDED NERVE SHEATHS HAVE NO ADVERSE-EFFECTS ON REGENERATION

Citation
L. Demedinaceli et al., LARGE AMOUNTS OF POLYLACTIC ACID IN CONTACT WITH DIVIDED NERVE SHEATHS HAVE NO ADVERSE-EFFECTS ON REGENERATION, Journal of reconstructive microsurgery, 11(1), 1995, pp. 43-49
Citations number
NO
Categorie Soggetti
Surgery
ISSN journal
0743684X
Volume
11
Issue
1
Year of publication
1995
Pages
43 - 49
Database
ISI
SICI code
0743-684X(1995)11:1<43:LAOPAI>2.0.ZU;2-Z
Abstract
The stumps of divided rat sciatic nerves were coapted by suturing the epineurium to a small rectangular device made of a sheet of polylactic acid. One month later, significant degradation of the implanted mater ial was observed. At that time, the local condition of the nerve was e xcellent, and the precise location of the initial injury could not be determined by examination under the operating microscope. Histology co nfirmed that there was no visible reaction to the biodegradable substa nce or its metabolites, and that neurotization of the distal stump was satisfactory. These findings were in agreement with those of other st udies, and indicated that polylactic-acid devices affixed to divided n erves have no adverse effect on regeneration.