EFFECT OF EGF DOSAGE FORMS ON ALKALI-BURNED CORNEAL WOUND-HEALING OF MICE

The local treatment effects of EGF forms on alkali burned mice corneal wounds were identified. The corneal wounds were induced by 0.5 M NaOH solution on the corneal surfaces of the mice. The local epidermal gro wth factor solutions (100 ng/ml) and gel form in 0.2 per cent w/w carb opol 940 (100 ng/ml) were dropped in 5 mu l aliquots into the eye twic e a day. The corneal wounds were measured for 15 days at 7-day interva ls and examined his;tologically at the end of 15th day of the experime ntal period. The results indicated that topical epidermal growth facto r treatment in solution improved the healing of alkali burned corneal wounds when compared with epidermal growth factor delivered in a polym er system.