The nucleotide sequence predicted to encode the precursor to virion st
ructural protein VI (preVI) of mouse adenovirus (Ad) serotype-1 (MAV-1
) was determined, The 237-amino-acid sequence has 45% identity and 66%
similarity to the human Ad serotype-2 preVI sequence, There is a mark
ed conservation at the C terminus, the last eleven residues of which m
ay be necessary for activating the Ad endoproteinase, and at the N ter
minus, including the consensus endoproteinase cleavage site.