Hemodynamically unstable ventricular arrhythmias induced during electr
ophysiologic testing almost always respond to prompt application of di
rect current transthoracic shocks. In rare cases, however, ventricular
fibrillation may be refractory to conventional treatment. Recently, a
technique of intracardiac defibrillation has been successfully used t
o resuscitate patients with ventricular fibrillation refractory to tra
nsthoracic defibrillation. We describe two patients with a history of
myocardial infarction and left ventricular dysfunction who were admitt
ed with symptomatic episodes of ventricular tachycardia. Both had indu
cible sustained monomorphic ventricular tachycardia. During a repeat e
lectrophysiologic study in Patient No. 1 on procainamide and at the in
itial study in Patient No. 2, right ventricular burst pacing to termin
ate ventricular tachycardia resulted in ventricular fibrillation refra
ctory to resuscitation efforts, including transthoracic defibrillation
with 360 J. Emergency intracardiac defibrillation with 200 and 360 J,
respectively, successfully converted both patients to sinus rhythm. B
oth patients were subsequently discharged from the hospital on amiodar
one. These cases illustrate the life-saving capabilities of intracardi
ac defibrillation.