CONCURRENCE OF ALZHEIMERS-DISEASE, PARKINSONS-DISEASE, DIFFUSE LEWY BODY DISEASE, AND AMYOTROPHIC-LATERAL-SCLEROSIS

A 71-year-old man developed signs of progressive dementia, followed by extrapyramidal and motor neuron disease symptoms, which led to death in 6 years. Neuropathological examination revealed neuritic plaques, n eurofibrillary tangles, and Lewy bodies in the substantia nigra and ne ocortex. Atrophy and gliosis with intraneuronal ubiquitin inclusions w ere present in the anterior horns of the spinal cord. Overlapping of A lzheimer's disease, Parkinson's disease, diffuse Lewy body disease and amyotrophic lateral sclerosis is rare and can increase our understand ing of the process of neurodegeneration.