CYTOGENETIC FINDINGS IN PEDIATRIC GERM-CELL TUMORS

Citation
F. Mertens et al., CYTOGENETIC FINDINGS IN PEDIATRIC GERM-CELL TUMORS, International journal of oncology, 6(2), 1995, pp. 401-404
Citations number
22
Categorie Soggetti
Oncology
ISSN journal
10196439
Volume
6
Issue
2
Year of publication
1995
Pages
401 - 404
Database
ISI
SICI code
1019-6439(1995)6:2<401:CFIPGT>2.0.ZU;2-R
Abstract
Three pediatric germ cell tumors (GCT) were cytogenetically analyzed. A mediastinal mature teratoma in a 15-year-old girl had a balanced t(8 ;22)(p21;q12) as the sole clonal aberration, an intrathoracic immature teratoma in a 2-year-old girl had the complex karyotype 46,XX,der(6) ;q11q23),de1(8)(q22),-1O,der(12)t(10;12),(q22;q22- 23),der(16)t(1;16)( q12;q11),+mar and a congenital presacral endodermal sinus tumor was ch aracterized by the karyotype dd(11)(p15),der(13)t(1;13)(q21;p13),add(1 4)(p13),d e1(15)(q24),+der(?)t(?;11)(?;q13). The present three tumors had no chromosome aberration in common, nor has any specific change be en detected in the 13 previously reported cytogenetically aberrant ped iatric GCT. The karyotypic picture comes across as far more heterogene ous than that of GCT of adults. Whereas gain of 12p material, in the v ast majority through i(12)(p10) formation, dominates in the adult sett ing, the most common cytogenetic abnormalities in pediatric GCT seem t o be unbalanced recombinations leading to gain of 1q. Other recurrent changes include, in decreasing order of frequency, numerical and struc tural aberrations leading to gain of 8q and 12p, loss of distal 1p, +3 , loss of 7q22-32, -10, -13 and -18.