CHANGES OF THE ACTIVITIES OF UREA CYCLE ENZYMES EXTRACTED FROM RAT-LIVER AFTER SURGICAL REDUCTION OF STOMACH CAPACITY AND AFTER FEEDING A HIGH-FAT DIET

Fourty-two Wistar FL tribe rats were divided into control groups, fed a high-fat diet or subjected to surgical reduction of stomach capacity by 75%. After 60 days of experiment we observed decrease of animal bo dy weight gain, as well as decrease of ornithine transcarbamylase and arginase activity. As indicated by the activity of these enzymes high- fat diet leads to an increase in urea cycle activity probably due to m etabolic and hormonal imbalance. The utilisation of carbamoylphosphate for the pyrimidine biosynthesis pathway did not seem to change the AT C-ase activity.