EFFECTS OF CALCISORB ON FECAL BILE-ACIDS AND FATTY-ACIDS IN HUMAN VOLUNTEERS

The intake of calcium (Ca) is negatively associated with colorectal ca ncer (crc) risk. The aim of this study was to investigate in a double- blind, placebo-controlled trial, the effects of the Ca-binder Calcisor b, which is given to kidney stone patients with hypercalciuria type I, on risk factors for crc risk, bile acids (BA), and long-chain fatty a cids (LCFA) in fecal water, Results show that the concentration of BA and LCFA in fecal water did not change, although the urinary excretion of Ca and magnesium (Mg) and the concentration of Ca and magnesium in fecal water decreased. The daily excretion of BA and LCFA acids decre ased significantly (p < 0.05) during the Calcisorb period. In conclusi on, binding dietary Ca and Mg with Calcisorb from a diet with a relati vely low amount of fat does not enhance the solubility of BA and LCFA in fecal water.