EXCLUSION OF THE CANDIDATE LOCUS FSP1 IN 6 FAMILIES WITH LATE-ONSET AUTOSOMAL-DOMINANT SPASTIC PARAPLEGIA

Hereditary spastic paraplegias are neurological hereditary conditions of unknown aetiology. In pure spastic paraplegia, most of the pedigree s display an autosomal dominant mode of inheritance. A gene for pure a utosomal dominant spastic paraplegia (ADSP), termed FSP1, was mapped t o chromosome 14q in a large pedigree with early-onset disease. This lo cus was tested by linkage analysis in six large French kindreds of ADS P with late-onset disease, using four microsatellites spanning a 9 cM interval including FSP1. FSP1 could be excluded in five of the six fam ilies, while no evidence for linkage was found in the remaining family . These results suggest that FSP1 is not involved in late onset ADSP, at least in the six families studied.