HIGH-PERFORMANCE LIQUID-CHROMATOGRAPHIC DETERMINATION OF PRAZIQUANTELIN PLASMA AND TISSUES OF CULTURED FISH FOR RESIDUE AND PHARMACOKINETIC STUDIES

Authors
HORMAZABAL V YNDESTAD M
Citation
V. Hormazabal et M. Yndestad, HIGH-PERFORMANCE LIQUID-CHROMATOGRAPHIC DETERMINATION OF PRAZIQUANTELIN PLASMA AND TISSUES OF CULTURED FISH FOR RESIDUE AND PHARMACOKINETIC STUDIES, Journal of liquid chromatography, 18(3), 1995, pp. 589-597
Citations number
13
Categorie Soggetti
Chemistry Analytical
Journal title
Journal of liquid chromatography → ACNP
ISSN journal
01483919
Volume
18
Issue
3
Year of publication
1995
Pages
589 - 597
Database
ISI
SICI code
0148-3919(1995)18:3<589:HLDOP>2.0.ZU;2-E
Abstract
A simple method for the determination of praziquantel in fish plasma a nd tissues by HPLC is presented. The samples were extracted with aceto ne, the organic layer then being separated with diethylether-hexane an d evaporated to dryness. The lower limit of quantification was 5, 15, and 20 mu g/kg, for muscle, liver, and plasma, respectively.