We compute the Donaldson SU(2)-invariants of the double cover of CP2 b
ranched over a smooth algebraic curve of degree eight. From this we de
duce a formula for the relative invariants of the blow-up of the Gompf
nucleus N2, and we show how this gives a blow-up formula for a class
of 4-manifolds which includes essentially all the simply connected 4-m
anifolds known to have big diffeomorphism group. We apply the result o
n the nucleus also to prove a formula for the invariants of minimal si
mply connected elliptic surfaces which reduces the computation to the
case of geometric genus one. In particular, we compute all the Donalds
on invariants of minimal simply connected elliptic surfaces without mu
ltiple fibers. Our main tool is Donaldson-Floer theory.