SUBSTANCE-P AND SEROTONERGIC INPUTS TO SYMPATHETIC PREGANGLIONIC NEURONS

Authors
PILOWSKY PM LLEWELLYNSMITH IJ MINSON JB ARNOLDA LF CHALMERS JP
Citation
Pm. Pilowsky et al., SUBSTANCE-P AND SEROTONERGIC INPUTS TO SYMPATHETIC PREGANGLIONIC NEURONS, Clinical and experimental hypertension, 17(1-2), 1995, pp. 335-344
Citations number
34
Categorie Soggetti
Pharmacology & Pharmacy","Cardiac & Cardiovascular System
Journal title
Clinical and experimental hypertension → ACNP
ISSN journal
10641963
Volume
17
Issue
1-2
Year of publication
1995
Pages
335 - 344
Database
ISI
SICI code
1064-1963(1995)17:1-2<335:SASITS>2.0.ZU;2-E
Abstract
Sympathetic preganglionic neurons are the final central links in the s ympathetic pathways that control the heart and blood vessels. The neur otransmitters present in the supraspinal pathways that control the act ivity of sympathetic preganglionic neurons Include amino acids, amines and peptides. In this paper we discuss evidence that suggests a role for serotonin and substance P in these pathways. Both of these neurotr ansmitters are present in bulbospinal neurons. Our results suggest tha t they have an important physiological role in the central regulation of blood pressure.