HIGH-PERFORMANCE LIQUID-CHROMATOGRAPHIC DETERMINATION OF TERGURIDE INSOLID DOSAGE FORMS AND PLASMA

A simple and rapid HPLC method was developed to determine terguride in terguride hydrogenmaleate, coated tablets and plasma. The assay was c arried out on a glass column of SGX CN (150 x 3.3 mm I.D.) using metha nol and phosphate buffer solution (pH 7.0) as the mobile phase, with d etection at 227 nm. Terguride was quantified using promethazine as an internal standard. The tablet matrix was extracted into methanol. Plas ma samples were deproteinated with acetonitrile and the supernatant wa s injected into the HPLC system. The method is linear, quantitative an d reproducible.