SUPPRESSION OF HALOPERIDOL-INDUCED ORAL DYSKINESIAS IN RATS BY VIGABATRIN

Acute and chronic administration of vigabatrin, a selective inactivato r of GABA-T, suppresses haloperidol-induced dyskinesias at low doses w ithout preventing the enhancement of striatal dopamine D-2 receptor de nsity or the development of vacuous chewing movements. The long-term a dministration of vigabatrin does not attenuate its effect. The observa tions presented in this work support the GABA hypothesis of haloperido l-induced vacuous chewing behavior in rats, and suggest that vigabatri n is an appropriate means to enhance nigral GABAergic activity.