CSF CONCENTRATIONS AND CLINICAL EFFECTS FOLLOWING INTRAVENOUS DIXYRAZINE PREMEDICATION

Single concurrent plasma and lumbar spinal fluid samples were collecte d from twenty-two patients given IV dixyrazine 0.15 mg/kg, 10-106 min earlier in an open study. Dixyrazine penetrated rapidly into the spina l fluid; the CSF/P ratio was 0.3 by 10 min after drug administration a nd persisted at that level during the study period. The uncontrolled s edative and anxiolytic effects assessed by the patients were slight, a nd were correlated with the CSF drug concentrations only during the fi rst 30 min after medication.