TOTAL SYNTHESIS OF PROINFLAMMATORY DIHYDRO-12-KETE METABOLITES

Authors
WANG SS SHI XX POWELL WS TIEMAN T FEINMARK SJ ROKACH J
Citation
Ss. Wang et al., TOTAL SYNTHESIS OF PROINFLAMMATORY DIHYDRO-12-KETE METABOLITES, Tetrahedron letters, 36(4), 1995, pp. 513-516
Citations number
9
Categorie Soggetti
Chemistry Inorganic & Nuclear
Journal title
Tetrahedron letters → ACNP
ISSN journal
00404039
Volume
36
Issue
4
Year of publication
1995
Pages
513 - 516
Database
ISI
SICI code
0040-4039(1995)36:4<513:TSOPDM>2.0.ZU;2-S
Abstract
The first total synthesis of the 10,11-dihydro-12-ketoeicosatetraenoic acid (10,11-dihydro-12-KETE) 5, a proinflammatory metabolite of 12-KE TE is reported. In addition, the total synthesis of two other potentia l metabolites of 12-KETE, namely 8,11-dihydro-12-KETE 6 and 8,9-dihydr o-12-KETE 7, is also described. These three synthetic compounds are ai med at investigating a new biosynthetic reductive pathway for 12-hydro xyeicosatetraenoic acid (12-HETE) and 12-KETE.