ELECTRON-TRANSFER REACTIVITY IN 5-NITROURACIL SERIES

Authors
CROZET MP GELLIS A PASQUIER C VANELLE P AUNE JP
Citation
Mp. Crozet et al., ELECTRON-TRANSFER REACTIVITY IN 5-NITROURACIL SERIES, Tetrahedron letters, 36(4), 1995, pp. 525-528
Citations number
18
Categorie Soggetti
Chemistry Inorganic & Nuclear
Journal title
Tetrahedron letters → ACNP
ISSN journal
00404039
Volume
36
Issue
4
Year of publication
1995
Pages
525 - 528
Database
ISI
SICI code
0040-4039(1995)36:4<525:ERI5S>2.0.ZU;2-R
Abstract
The sodium salt of 1,3,6-trimethyl-5-nitrouracil is shown to react wit h various reductive alkylating agents such as p-nitrobenzyl chloride a nd dinitropropane by an S(RN)1 mechanism to give new potentially bioac tive 5-nitrouracil derivatives. 1,3-Dimethyl-5-nitro-6-chloromethylura cil also reacts by an S(RN)1 mechanism with 2-nitropropane anion to af ford a new uracil derivative being a trisubstituted ethylenic double b ond at the 6-position.