ASYMMETRIC KETONE REDUCTION USING CHIRAL OXAZABOROLIDINES DERIVED FROM AZIRIDINE CARBINOLS

Authors
WILLEMS JGH DOMMERHOLT FJ HAMMINK JB VAARHORST AM THIJS L ZWANENBURG B
Citation
Jgh. Willems et al., ASYMMETRIC KETONE REDUCTION USING CHIRAL OXAZABOROLIDINES DERIVED FROM AZIRIDINE CARBINOLS, Tetrahedron letters, 36(4), 1995, pp. 603-606
Citations number
28
Categorie Soggetti
Chemistry Inorganic & Nuclear
Journal title
Tetrahedron letters → ACNP
ISSN journal
00404039
Volume
36
Issue
4
Year of publication
1995
Pages
603 - 606
Database
ISI
SICI code
0040-4039(1995)36:4<603:AKRUCO>2.0.ZU;2-D
Abstract
Asymmetric borane reduction of acetophenone using 1,3,2-oxazaborolidin es derived from aziridine-2-tertiairy alcohols 1 and 2 yielded the cor responding alcohol in high optical yields. The synthesis of the novel chiral catalysts 1 and 2 using D- and L-serine, and D- and L-threonine as starting material is described.