We assessed markers of anomalous cerebral dominance in 70 problem drin
kers at risk for alcoholism, 43 alcoholics who had been sober for at l
east six months, and 311 healthy control subjects age-matched to the p
roblem drinkers. Markers of anomalous cerebral dominance included left
-handedness, learning disabilities, neuro-immune disorders, and specia
l cognitive talents. We also administered a ''drinking inventory'' to
assess frequency and severity of drinking patterns for self and family
. Analysis showed elevated rates of left-handedness and learning disab
ilities in the alcoholic group and in the ''at risk'' problem drinkers
. These same subjects rated themselves and their families as relativel
y poor at left-hemisphere-mediated cognitive talents. Alcoholic women
evidenced significantly greater incidence of immune disorders than alc
oholic men. Alcoholism appears to be related to biological factors whi
ch have been associated with anomalous cerebral dominance.