Inherited forms of iron overload are common. HLA-linked hemochromatosi
s and possibly African iron overload are associated with a significant
risk of developing hepatocellular carcinoma. Early diagnosis and trea
tment, before substantial iron overloading occurs, reduces morbidity a
nd mortality. HLA-linked hemochromatosis is easily diagnosed, and rout
ine screening in European-derived populations may be appropriate.