In a sample of 276 Japanese adult patient attenders at two primary car
e clinics affiliated with the Department of Hygiene and Preventive Med
icine at the Okayama University Medical School major depression was di
agnosed in 5.8% and minor depression in 7.2% of patients studied. Func
tional impairment was significantly more severe in patients with eithe
r major or minor depression than in those not affected. None of the 36
patients with major or minor depression had received a diagnosis of d
epression or had been given antidepressant therapy. Possible explanati
ons for the marked underdiagnosis of depression and lack of specific a
ntidepressant therapy in these patients include severe stigma associat
ed with a diagnosis of mental disorders, focus of the mental health sy
stem on hospitalization with consequent trivialization of mental probl
ems in ambulatory patients, and the extraordinarily high work load of
primary care doctors.