1. This study examined the influence of brisk walking on skeletal stat
us in post-menopausal women. 2. Subjects were 84 healthy women aged 60
-70 years who were previously sedentary and at least 5 years post-meno
pausal. Subjects were randomly assigned to walking (n = 43) and contro
l (n = 41) groups. Walkers followed a 12-month, largely unsupervised p
rogramme of brisk walking. The bone mineral density of the lumbar spin
e, femoral neck and calcaneus and broadband ultrasonic attention of th
e calcaneus were measured at baseline and after 12 months, 3. Forty co
ntrol subjects and 38 walkers completed the study, Walkers built up to
20.4 +/- 3.8 min/day (mean +/- SD) of brisk walking, Body mass increa
sed in control subjects relative to walkers [mean change (SE) + 0.9 (0
.3) and - 0.1 (0.3) kg respectively; P = 0.04], Predicted maximum oxyg
en uptake increased in walkers by 2.1 (0.9) ml min(-1) kg(-1) (P = 0.0
2), Bone mineral density in the lumbar spine and calcaneus fell in con
trol subjects [- 0.005 (0.004) and - 0.010 (0.004) g/cm(2), respective
ly] but not in walkers [+ 0.006 (0.004) and + 0.001 (0.004) g/cm(2)].
The difference in response between groups was significant in the calca
neus (P = 0.04) but not in the lumbar spine (P = 0.08), Mean femoral n
eck bone mineral density did not change significantly in either group,
although changes in walkers were related to the amount df walking com
pleted (r = 0.51, P = 0.001). The change in broadband ultrasonic atten
uation of the calcaneus differed between groups [control subjects, - 3
.7 (0.8); walkers, - 0.7 (0.8) dB/MHz; P = 0.01], 4. Walking decreased
bone loss in the calcaneus and possibly in the lumbar spine. It also
improved functional capacity and enabled walkers to avoid the increase
in body mass seen in control subjects.