HPLC DETERMINATION OF THE STABILITY OF RETINOIC ACID IN OVULE FORMULATIONS FOR THE TREATMENT OF CERVICAL DYSPLASIA RELATED TO PAPILLOMAVIRUS

We studied the efficacy of all-trans-retinoic acid-containing ovules i n combination with an alpha-interferon-based gel and Decapeptyl degree s IM in the treatment of cervical papillomavirus infections and intrae pithelial dysplasia. Stability tests showed that the retinoic acid in the ovules was stable for at least 4 months at 4 degrees C. In a pilot study, we obtained complete remissions with the three-drug combinatio n, whereas all-trans-retinoic acid and alpha-interferon used alone pro duced only partial remissions; Decapeptyl degrees also induced the dis appearance of similar lesions, but was associated with recurrences due to persistence of the virus.