IVERMECTIN INDUCED TOXICOSIS IN A DOG - T REATMENT WITH PENTILENETETRAZOL

A one year-old bitch, with 25-30 kg body weight, subcutaneously receiv ed a 200 mu g/kg dose of ivermectin as treatment for a demodex mange. Fifteen minutes after drug administration, adverse signs of salivation , vomiting, ataxia, dispnea, tachycardia, muscular tremors and unrespo nsiveness to external stimuli were observed. Twenty-four hours after i nitiating treatment with a 10% solution of pentilenetetrazol in dosis of 20 drops, orally, every 6 hrs, the symptoms were reversed and the l ocomotive activity and alertness of the animal were recovered. The pos sible action of ivermectin as a gamma aminobutiric receptor agonist at CNS level and the probable antagonism to pentilenetetrazol is discuss ed.