INVESTIGATIONS ON THE STEROIDAL ANTIINFLAMMATORY ACTIVITY OF TRITERPENOIDS FROM DIOSPYROS-LEUCOMELAS

Authors
RECIO MD GINER RM MANEZ S GUEHO J JULIEN HR HOSTETTMANN K RIOS JL
Citation
Md. Recio et al., INVESTIGATIONS ON THE STEROIDAL ANTIINFLAMMATORY ACTIVITY OF TRITERPENOIDS FROM DIOSPYROS-LEUCOMELAS, Planta medica, 61(1), 1995, pp. 9-12
Citations number
11
Categorie Soggetti
Pharmacology & Pharmacy","Plant Sciences
Journal title
Planta medica → ACNP
ISSN journal
00320943
Volume
61
Issue
1
Year of publication
1995
Pages
9 - 12
Database
ISI
SICI code
0032-0943(1995)61:1<9:IOTSAA>2.0.ZU;2-4
Abstract
Three triterpenes were isolated from Diospyros leucomelas and identifi ed as betulin, betulinic acid, and ursolic acid. They showed anti-infl ammatory activity in the carrageenan and serotonin paw edema tests and TPA and EPP ear edema tests. The blockade of their effects by progest erone, actinomycin D, and cycloheximide has served to determine the me chanism of action in relationship with that of glucocorticoids. Betuli nic acid was the most affected and therefore a mode of action similar to these drugs may be postulated for it.