NATURALLY-OCCURRING PROTEIN-KINASE-C INHIBITORS .2. ISOLATION OF OLIGOMERIC STILBENES FROM CARAGANA-SINICA

Authors
KULANTHAIVEL P JANZEN WP BALLAS LM JIANG JB HU CQ DARGES JW SELDIN JC COFIELD DJ ADAMS LM
Citation
P. Kulanthaivel et al., NATURALLY-OCCURRING PROTEIN-KINASE-C INHIBITORS .2. ISOLATION OF OLIGOMERIC STILBENES FROM CARAGANA-SINICA, Planta medica, 61(1), 1995, pp. 41-44
Citations number
22
Categorie Soggetti
Pharmacology & Pharmacy","Plant Sciences
Journal title
Planta medica → ACNP
ISSN journal
00320943
Volume
61
Issue
1
Year of publication
1995
Pages
41 - 44
Database
ISI
SICI code
0032-0943(1995)61:1<41:NPI.IO>2.0.ZU;2-#
Abstract
The oligomeric stilbenes (+)-alpha-viniferin (1), miyabenol C (2), and kobophenol A (3) have been isolated from Caragana sinica (Buchoz) Reh d (Leguminosae). (+)-alpha-Viniferin (1) and miyabenol C (2) exhibited protein kinase C inhibitory activity at low micromolar concentrations . (+)-alpha-Viniferin inhibited keratinocyte proliferation (0.4 mu M) and free radical release in whole blood (47 mu M), in vitro, and may b e useful in treating hyperproliferative or inflammatory skin diseases.