CYTOTOXIC ACTIVITY OF AMARYLLIDACEAE ALKALOIDS

25 Amaryllidaceae alkaloids belonging to different skeletal types were evaluated for their cytotoxic activity against one murine non-tumoral cell line (LMTK) and two human tumoral cell lines (Molt4 and HepG2) a ccording to established protocols. Significant differences of activity related with the type of skeleton of the tested alkaloids could be ob served. Pretazettine (22) was among the most active compound among the 25 tested alkaloids on the Molt4 lymphoid cells, but was inactive aga inst HepG2 hepatoma. On the other hand, lycorenine (11) was found to b e the most cytotoxic compound against HepG2 hepatoma, even though it a ppears to be inactive against Molt4 cells. Almost all of the tested al kaloids showed cytotoxic activity against fibroblastic LMTK cells. Onl y mesembrenone (25) showed some specificity against Molt4 cells in com parision to LMTK cells.