SYNTHESIS AND BIOLOGICAL EVALUATION OF 3-HYDROXYMETHYLPYRIMIDO[1,6-C][1,3]OXAZINE DERIVATIVES

Authors
HSU LY LIN CH
Citation
Ly. Hsu et Ch. Lin, SYNTHESIS AND BIOLOGICAL EVALUATION OF 3-HYDROXYMETHYLPYRIMIDO[1,6-C][1,3]OXAZINE DERIVATIVES, Heterocycles, 43(12), 1996, pp. 2687-2699
Citations number
15
Categorie Soggetti
Chemistry Inorganic & Nuclear
Journal title
Heterocycles → ACNP
ISSN journal
03855414
Volume
43
Issue
12
Year of publication
1996
Pages
2687 - 2699
Database
ISI
SICI code
0385-5414(1996)43:12<2687:SABEO3>2.0.ZU;2-0
Abstract
A number of 5-substituted 3-hydroxymethylpyrimido[1,6-c][1,3]oxazine d erivatives were synthesized and evaluated for their biological activit y. Compound (10) showed slight activity (GI(50) = 2.7 mu M) against MD A-MB-231/ATTC Breast Cancer cell line.