FLOW-INJECTION FLUOROMETRIC ANALYSIS OF SULFAMETHOXAZOLE IN PHARMACEUTICAL PREPARATIONS AND BIOLOGICAL-FLUIDS

Authors
ERROZ CL VINAS P CORDOBA MH
Citation
Cl. Erroz et al., FLOW-INJECTION FLUOROMETRIC ANALYSIS OF SULFAMETHOXAZOLE IN PHARMACEUTICAL PREPARATIONS AND BIOLOGICAL-FLUIDS, Talanta, 41(12), 1994, pp. 2159-2164
Citations number
13
Journal title
Talanta
ISSN journal
00399140 → ACNP
Volume
41
Issue
12
Year of publication
1994
Pages
2159 - 2164
Database
ISI
SICI code
0039-9140(1994)41:12<2159:FFAOSI>2.0.ZU;2-2
Abstract
A fluorimetric procedure for the determination of sulfamethoxazole usi ng flow injection analysis is proposed. A two channel system is optimi zed for the fluorescent reaction with o-phthaldialdehyde and beta-merc aptoethanol. The detection limit is 0.007 mu g/ml. No fluorescence is generated by the metabolite N-acetylated sulfamethoxazole. The method is applied to the determination of sulfamethoxazole in pharmaceuticals , urine and bovine serum samples without matrix interference problems.