APPLICATION OF QUANTITATIVE CORONARY ANGIOGRAPHY IN A CINELESS ENVIRONMENT - IN-VIVO ASSESSMENT OF A FULLY AUTOMATED-SYSTEM FOR CLINICAL USE

The accuracy and precision of a fully automated quantitative coronary angiography (QCA) algorithm for use in a cineless environment were det ermined in phantom studies and in an in vivo canine preparation. Imagi ng studies of 118 coronary segments in six anesthetized dogs were comp ared with measurements of the diameters of casts of the canine coronar y arteries produced in physiologic conditions. Regression analysis of phantom vessel diameters against QCA measurements revealed slopes of 0 .94 to 0.96 and r values >0.99. The results of the in vivo studies sho wed good correlation with the coronary cast diameter measurements, wit h a slope of 0.969 and an r value of 0.987 for the sets of measurement s. The high degree of accuracy obtained in a model representative of t he clinical situation demonstrates that QCA methods can be applied rel iably in the clinical arena with current digital imaging technology an d without cinefilm.