KAPOSIS-SARCOMA FOLLOWING ALLOGENEIC BONE-MARROW TRANSPLANTATION

Localised Kaposi's sarcoma (KS) was diagnosed 240 days after allogenei c bone marrow transplantation (BMT) in a severely immunosuppressed HIV negative patient with genetic predisposition. The tumour was of host origin, based on PCR amplification of DNA minisatellites. Treatment wi th radiotherapy prompted almost complete regression of the lesions. Ho wever the patient subsequently died with relapsed acute myelogenous le ukaemia. Contrary to the incidence observed after organ allografts, th e advent of KS appears to be exceptional after BMT, since only one cas e has been reported to date, following reinfusion of autologous marrow .