FUNCTIONAL REORGANIZATION IN THALAMOCORTICAL NETWORKS - TRANSITION BETWEEN SPINDLING AND DELTA SLEEP RHYTHMS

Thalamic reticularis, thalamocortical, and cortical cells participate in the 7-14-hz spindling rhythm of early sleep and the slower delta rh ythms of deeper sleep, with different firing patterns, In this case st udy, showing the interactions of intrinsic and synaptic properties, a change in the conductance of one kind of cell effectively rewires the thalamocortical circuit, leading to the transition from the spindling to the delta rhythm, The two rhythms make different uses of the fast ( GABA(A)) and slow (GABA(B)) inhibition generated by the thalamic retic ularis cells.