From the sixties on it has become clear how the human physical conditi
on could be influenced by human behavior. Although hypothesis were lac
king to understand these connections, nursing research especially prov
ed how systematically introduced patient behavior during illness and h
ospitalization could induce better recovery results and better prognos
is for the patient. Information and attitude proved to be crucial elem
ents in these processes of improved patient expectations. It took less
than two decades to get to the insights we have in 1994. Recent resea
rch shows the interlocking mechanisms of nervous and endocrine systems
with the immune system as significantly being influenced by behavior
and especially psychic and or psychosocial stress. This special issue
of Theoretical Medicine briefly describes the historical development w
ith contributions on the most recent state of the scientific art. Thes
e developments are emphasized by discussion on the clinical reality of
the (breast) cancer patient and recent findings on the complexity of
the prevalence of cancer in epidemiology. An attempt is made to consid
er practical consequences of the actual knowledge if applied to patien
t care.